The first rule of integrating Adsense into your website is to acknowledge that your visitors will see and interact with your Adsense ads the way you see them and have consequently integrated them. If you think of the time you have spent deciding colors, site structure, images and everything else that makes your website, the same amount of energy and precision should go into getting Adsense just right on your webpages.
As you have complete control over the design and layout of your webpages, you also have complete control over how a visitor interprets and ultimately interacts with your pages - and this includes your Adsense Ads.
First and foremost, the size and placement of your ads suggests to the visitor how he or she ought to interact with them. For example,
1. If you use a 728 x 90 leaderboard at the top of your page you are saying to your visitors - "here are some ads which I do not consider to be actually part of my website but I hope that they will catch your eye as you look to the actual content of my website".
2. If you use a 120 x 600 skyscraper in either your left or right navigation you are saying to your visitor, these ads are like my navigation, something extra to the page which you are currently on and to be used like the rest of my navigation if something in them takes your fancy.
3. If you use one of the square or rectangle shapes inside your actual page content, you are saying to your visitors that "these ads are integral to the content of this page and should be read as you are reading the rest of these words - as content relating to the actual page topic".
Needless to say the last of these will always perform better than the other two examples.
View Adsense ads as supplemental content to your page content, integrate them into the structure of your webpages that way and your visitors will interact with them that way giving you a much higher click through rate.
This is the first step to success with Adsense. If you view Adsense as just an easy way to make a couple of extra dollars that's all you will do with it. If you take the time to structure your website and integrate Adsense so as to supplement the page content your click through rate and your earnings will go through the roof.
There are many ways to do this successfully and many different sites that Adsense can work on.
Article from understandingadsense.com